PHARMACOLOGY MOCK TEST I

Which of the following is unlikely to be associated with oral drug administration of an enteric-coated dosage form?

Which of the following is classified as belonging to the tyrosine kinase family of receptors?

Following drugs lower the interocular pressure
[P] Pilocarpine [Q]Lananoprost
[R] Atropine [S] Tiotropium

M2 receptor is responsible for following effects:
[P] Cardiac inhibition [Q]Neural inhibition
[R] Gastric secretion [S] Vasodilatation

Following are the antagonist of muscarinic receptor:
[P] Oxotremorine [Q]Oxybutynin
[R] Tolterodine [S] Carbacho

Following are the antagonist of nicotinic receptor
(α1)2
:
[P] Cytosine [Q]Epibatidine
[R] Atracurium [S] Vecuronium

Following are the agonist of nicotinic receptor (α3)2
:
[P] Carbachol [Q]Trimetaphan
[R] Hexamethonium [S] Acetylcholine

Following statements are true:
[P] GABA transmitter is responsible for peristaltic
reflex
[Q]Neuropeptide Y facilitates constrictor action of
adrenaline and inhibits adrenaline release
[R] Substance P is co-transmitter with acetylcholine
[S] Dopamine transmitter is responsible for vasoconstricto

Following statements are true:
[P] Substance P is located at sympathetic ganglia
[Q]Neuropeptide Y is located at postganglionic sympathetic neurons
[R] Nitric oxide located at enteric neurons
[S] Gonadotrophin-releasing hormone is not located at
sympathetic ganglia

Cholinergic M2 - and M3
- receptors produce following
effects:
[P] Decreased heart rate
[Q]Dilatation effect on salivary gland
[R] Increased heart rate
[S] Effect on erectile tissue

Most common Phase-II reaction is

Which of the following receptor shows the slowest
response?

Which of the following is CYP450 enzyme inhibitor?

Bioassays are carried out to:

Isolated rabbit jejunum is used

Following drugs have volume of distribution more
than 200:

P] Warfarin [Q]Amitryptyline
[R] Digoxin [S] Alcohol

In the bioassay the convulsion activity in mice is
observed during __________ use.

Acetylcholine and physostigmine are examples of
__________ type drug interaction.

Following are the chloride channel blocker
[P] Amiloride [Q]Cadmium
[R] Picrotoxin [S] Ketamine

pA2
can be defined as

Phentolamine is competitive antagonism of

Drug having high affinity but low intrinsic activity is
called

pD2
value means

Morphine’s affects the eye by:

Most of the drug is absorbed through

Spironolactone is a prodrug and its active metabolite is

Following drug have less than 50% protein-binding
capacity
[P] Insulin
[Q]Aminoglycoside antibiotic
[R] Diazepam
[S] Aspirin

Following drug have more than 99% protein-binding
capacity
[P] Digoxin [Q]Aspirin
[R] Thyroxine [S] Warfarin

Transport diffusion is proportional to concentration
gradient in
[P] Active transport
[Q]Facilitated diffusion
[R] Passive diffusion
[S] Ion pair transport

Following statement are true for facilitated diffusion:
[P] It is unsaturable
[Q]It is Non selective
[R] It is energy dependent
[S] It is energy independent

Following statements are true for passive diffusion:
[P] It is saturable
[Q]It is nonselective
[R] It is energy dependent
[S] It is energy independent

MgSO4
exerts their various effects through following
route are true:
[P] It produces purgative effect if given orally
[Q]It produces depressant effect if given parenterally
[R] It does not produce any effect if given parenterally
[S] It increases intracranial tension if given enema

Following statements are true for intradermal route:
[P] The drug is injected under skin
[Q]This route is used for testing sensitivity to drug
like penicillin
[R] The drug is given within the skin layer
[S] Special process of infusing large amount of drugs
like glucose

Following statements are true:
[P] An epidermic means simple application of medicament on the skin
[Q]An epidermic means application of medicament
by rubbing
[R] Iontophoresis means application of medicament
to and pushing it through skin to reach the blood
vessels by electric transmission
[S] Inunction means simple application of medicament
on the skin

. Muscarinic receptor M3 are mainly located at
[P] Exocrine gland [Q]Cerebral cortex
[R] Heart [S] CNS

Mechanism of action of organic phosphate parathion is

Propranolol is contraindicated in patients with

Pilocarpineis classified as

Orally effective sympathomimetics agent is

[P] Epinephrine [Q]Isoproterenol
[R] Ephedrine [S] Amphetamine

Atropine over dosage may causes all of the following
except

Following statement is true for labetalol
[P] It is α and β antagonist
[Q]It produces tachycardia as side effect
[R] It is non-selective β antagonist
[S] It is used in hypertension in pregnancy

Following statements are true for ritodrine
[P] It is β2
agonist
[Q]It produces arrhythmia as side effect
[R] It is β1
agonist
[S] It is used for nasal decongestion

Following statements are true for β2
receptor

[ P] It produces glycogenolysis effect
[Q]It produces lipolysis effect
[R] It relaxes uterus
[S] It produces constriction effect on bronchi

Neostigmine may cause all of the followings except

Epinephrine is added to local anaesthetics

Which of the following drug may cause cycloplegia
when used topically in the eye?

. In the treatment of myasthenia gravis, the best agent
for distinguishing between myashenic crisis and cholinergic crisis, given intravenously, is

Following statements are true:
[P] Hemicholinium inhibits the acetylcholine
synthesis
[Q]Parathion is a short duration anticholineterase
[R] Botulinum toxin inhibits acetylcholine release
[S] Physostigmine is used in treatment of myasthenia
gravis

The main side effect of tubocurarine is
[P] Bradycardia [Q]Bronchoconstriction
[R] Hypotension [S] Cardiac arrhythmia

In urinary incontinence following drug is widely
used:

Desmopressin

Warfarin interacts with this antiasthmatic drug and
increases prothrombin time

Which drugs increase ADH effect?

Drug for therapy of acromegaly (a condition in which
there is oversecretion of growth hormone in an adult)
and of bleeding oesophageal varices is ____________.

Which of the following is IL-1 antagonist?

Which of the following drug increases the sensitivity
of β-cells to glucose?

Which of the following increases the tissue sensitivity
to insulin?

The accumulation of __________ in the lens produces
cataracts in diabetic patients:

Gout is characterized by elevated uric acid concentra
tions in blood and urine due to a variety of metabolic
abnormalities that lead to the overproduction of purine
nucleotides. Allopurinol is used in the treatment of
gout because this drug, and its metabolic product,
alloxanthine, act as inhibitors of

The binding of insulin to the insulin receptor triggers