MEDICINAL CHEMISTRY MOCK TEST I According GPAT Pattern

A MEDICINAL CHEMISTRY MOCK TEST I is an essential tool for pharmacy students, such as those pursuing a Bachelor of Pharmacy (B. Pharma) or GPAT preparation, to assess their understanding of the subject. This test typically covers various topics in Pharmaceutics, including drug formulation, dosage forms, drug delivery systems, pharmaceutical calculations, and more.

MEDICINAL CHEMISTRY MOCK TEST

Each question carries 4 marks.
For every wrong answer, 1 mark will be deducted.
The time allowed for each mock test is 30 minutes for a 60-question.

1 / 60

Oxime is not used as antidote for

Tabun

Dyflos

Echothiophate

Neostagmine

2 / 60

hich of following synthetic anticholinergic derivative is used in Parkinson disease?

Amino alcohol ester

Amino amide

None

Amino alcohol ether

3 / 60

Which is TXA2
synthesis inhibitor (imidazole analogue

Moxonidine

Dazoxiben

Aspirin

Ridogrel

4 / 60

The anti- malarial drug quinine contains

Isoquinoline ring

Quinclidine ring

Quinoline ring

Both (a) and (b)

5 / 60

Which of the steroids have neuromuscular blocking
activity?

Estrogen

Fusidin

Digitoxigenin

Pancuronium

6 / 60

Isoniazid is synthesized from

Methyl ester of nicotinic acid+ hydrazine

Methyl ester of is isonicotinic acid+ Methyl hydrazine

Methyl ester of isonicotinic acid+ hydrazine

Methyl ester of is nicotinic acid+ Phenyl hydrazine

7 / 60

Dipivefrin is prodrug of

Noradrenaline

Both

None

Adrenaline

8 / 60

Hypoglycemic agent with 1-(hexa hydro-1H-azepin1-yl)-3-(p-tolyl sulphonyl) urea is

Tolazamide

Tolbutamide

GliCiazide

Gliburide

9 / 60

Which agent is used in Athlet’s foot?

Haloprogin

5-Flucytosin

Clioquinol

Cicloprox

10 / 60

Compounds that have both TXA2
synthetase inhibition
as well as TXA2
receptor blocking activity is

Aspirin

Moxonidine

Dazoxiben

Ridogrel

11 / 60

3-Hydroxy-estra-1,3,5 (10)-trien-17-ones is

Dienesterol

Estradiol

Estrone

3-Hydroxyestrone

12 / 60

Timolol contains which of following basic rings:

1,2,5-Thiadiazole and morpholine

1,2,4-Thiadiazole and morpholine

1,4-Thiazole and morpholine

None

13 / 60

Amodiaquine Iminoquinone is ___________ product
of amodiaquin

Oxidized

Alkylating

None of the above

Reduced

14 / 60

Which of the following have estrogenic activity?

Gossypol

Both (b) and (c)

Genistein

Coumesterol

15 / 60

Which of long acting beta blocker is used for glaucoma?

Betaxolol

Carteolol

Levabunolol

Timolol

16 / 60

The basic ring present in nizatidine is

Thiazole

Imidazole

None

Furan

17 / 60

Clonidine is used as:

Glucoma

Migraine

All

Opioid withdrawal syndrome

18 / 60

The anti arrythmatic drug quinidine is a

(+) Racemic mixture of quinine

None of the above

(–) Stereoisomer of quinine

(+) Stereoisomer of quinine

19 / 60

For a molecule to exhibit antihistaminic activity the
distance between the aryl and aliphatic N should be?

4–5 A°

2–3 A°

1–2 A°

5–6 A°

20 / 60

Which sulfonamides produces “Orange yellow color
to urine” under alkaline condition?

Sulfadiazine

Sulfacetamide

Sulfasalazine

Sulfamethoxazole

21 / 60

Which of following is hydrophilic organophosphate
compound?

None

Malathion

Ecothiophate

Parathion

22 / 60

Which of the following drug is used as mydriatic when
cyclopegia is not required?

Phenoxybenzamine

None

Hydroxyamphetamine

Phenylephrine

23 / 60

Which of following is propylamine derivative?

Triprolidine

None

Antazoline

Azotidine

24 / 60

What is the starting material for synthesis of salbutamol?

4-Hydroxy propiophenone

Mesitylene derivatives

Methyl salicylate

Phenyl acetonitrile

25 / 60

Pseudoepedrine is a

Erythro isomer

Threo isomer

Meso isomer

Racemic mixture 140.

26 / 60

Which of following selective β2 -agonists contains
pyridine ring?

Albuterol

Terbutaline

None

Pirbuterol

27 / 60

Which of following is metabolite of hydroxyzine?

Loratadine

Astemizole

Cetrizine

28 / 60

Which one of the following drugs does not act through
G protein coupled receptors?

Dopamine

TSH

Epinephrine

Acetylcholine

29 / 60

Phenoxybenzmine acts:

By forming ethylene iminium ion which blocks α-receptor

By forming aziridinium ion which blocks α receptor

All of above

By irreversibly blocking α-receptor

30 / 60

Which isomer of emetine is clinically useful?

Levo

Dextro

31 / 60

Which of following inhibits ketoconazole absorption?

Cimetidine

Ranitidine

Famotidine

Nizatidine

32 / 60

Which of following selective β2–agonists is not metabolized by COMT?

Albuterol

Terbutaline

All

Pibuterol

33 / 60

Clonidine, metronidazole and tinidazole have which of
the group in common?

Quinidine

None of the above

Benzimidazole

Imidazoline

34 / 60

Which of the following adverse effects is not associated with INH?

Ototoxicity

Hepatotoxicity

Xerostomia

Peripheral neuritis

35 / 60

Which of the following is use in the diagnosis of
myasthenia gravis?

Neostigmine

Both

None

Physostigmine

36 / 60

Which of the following is a progesterone antagonist?

Mifepristone

Both (a) and (b)

Danazol

Gossypol

37 / 60

Which alkaloid is used to treat amoebiasis?

Ipecac

Theophylline

Brucine

Aconite

38 / 60

The basic ring present in cicloprox is

2-Pyridone

2-Pyridine

2-Pyrrolidine

2-Piperidone

39 / 60

Following drugs have a asymmetric centre except

Primaquin

Quinocide

Pamaquin

Pentaquin

40 / 60

17 β-Hydroxyandrost-4-en-3-one is

Prosgesterone

Floxymestrenone

Testosterone

Estriol

41 / 60

rinic receptor contains which of the following amino acids as residue for parasympathetic activity?

Glutamic acid

Glutamine

Aspartic acid

Aspargine

42 / 60

Which of the following imdazoline derivatives is selective
α2 agonist?

Tolazoline

Naphazoline

Clonidine

None

43 / 60

Which is not a true for isoniazid?

It inhibit Mycolase Synthase

It is hydrazide of isonicotinic acid

Structurally similar to pyridoxine

It is hydrazide of nicotinic acid

44 / 60

Anesaldehyde is a starting material for synthesis of

Chlortrienisene

Diethyl stilbesterol

Dexamethasone

Trans stilbene

45 / 60

Which of following is selective novel M-3 antagonist?

Pirenzepine

Drotaverine

All

Darcifenacin

46 / 60

Coloroquin act by inhibiting following enzyme

DNA and RNA polymerase

DNA gyrase

Dihydro folate reductase

DNA synthase

47 / 60

Which of the following is β-halo alkyl amine derivative?

Phenoxybenzamine

Phenotamine

None

Tolazoline

48 / 60

The basic ring present in pilocarpine is:

None

Tetrahydrofuran and Indole

Tetrahydrofuran and Pyrole

Tetrahydofuran and Imidazole

49 / 60

Which of following is used in Alzheimer disease?

Ambenonium

Arecoline

Demecarium

Oxotremorine

50 / 60

Which of the following have anti estrogenic activity?

Cyproterone

Flutamide

BOMT

All of the above

51 / 60

Phenoxybenzmine acts

All of the above

Directly on alpha receptor

By form ethylene iminium ion.

By irreversibly block alpha receptor

52 / 60

Which isomer of propranolol is more active?

Racemic

Dextro

Meso

Levo

53 / 60

17-β-hydroxyl androst-4-ene-3-one is IUPAC of

Estriol

Estradiol

Testosterone

Cortisone

54 / 60

Which antibiotic has direct action on trophozoitocidal?

Neomycin

Natamycin

Erythromycin

Paramomycin

55 / 60

A steroid nucleus having 19 carbon is _________

Gonane

Estrane

Androstane

Cholestane

56 / 60

Which of following drug inhibits dopa hydroxylase in
noadrenaline synthesis?

Alpha methyl dopa

Levodopa

Disulfiram

Carbidopa

57 / 60

Which of following is metabolite of hydroxyzine?

Cetrizine

Terfenadine

Loratadine

Astemizole

58 / 60

Which nitroimidazole derivative has morpholino moiety?

Tinidazole

Ornidazole

Metronidazole

Timorazole

59 / 60

Which of the following is aryl sulfonamide derivative?

Prazosin

Tamsulosin

Metaraminol

None

60 / 60

Which of the following adverse effects is not associated with rifampin?

Flu-like syndrome

Xerostomia

Hepatitis

Red orange color to urine

Your score is

MEDICINAL CHEMISTRY MOCK TEST I

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